Polychlorinated biphenyl isomers in the blood and biopsy fat specimens of a selected population of British Columbia (Canada)

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Abstract
Twenty-five blood and biopsy fat samples were collected from donors with and without a Down''s Syndrome child, and analyzed for 29 selected polychlorinated biphenyl isomers. Differences in polychlorinated biphenyl isomer levels in blood and adipose tissue of donors with or without a Down''s Syndrome child were not statistically significant. Most polychlorinated biphenyl isomers observed in blood were also detected in adipose tissue, except for the 3,4,4''-trichlorobiphenyl, which was sometimes observed in blood, but not in adipose tissue. The blood/adipose tissue ratios of the polychlorinated biophenyl isomers indicated lower and more constant ratios for the higher chlorinated congeners. No significant differences were observed for the polychlorinated biphenyl isomer levels in blood of males and females, while in adipose tissue only the 2,4,4''-trichloro-2,3,4,3'',4''-pentachloro- and 2,3,4,5,6,2'',3'',4'',5''-nonachlorobiphenyl congeners were significantly (p<0.05) different between the sexes. Donors, who gained weight in the year prior to sample collection, showed significant (p<0.05) lower levels of several isomers in blood lipids.