Phosphoramidites: Marvellous Ligands in Catalytic Asymmetric Conjugate Addition
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- 31 May 2000
- journal article
- review article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 33 (6) , 346-353
- https://doi.org/10.1021/ar990084k
Abstract
The development of an efficient catalytic system for enantioselective carbon−carbon bond formation by 1,4-addition of organometallic reagents (organolithium, Grignard, and organozinc reagents) to enones is a major challenge in organic synthesis. This Account presents the breakthrough realized in this field using chiral phosphoramidite ligands for copper-catalyzed dialkylzinc additions. Applications in catalytic routes to cycloalkanones as well as tandem and annulation procedures with excellent enantioselectivities are discussed.Keywords
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