Flow-volume curves and total pulmonary resistance in normal bonnet and rhesus monkeys
- 1 January 1979
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 46 (1) , 176-183
- https://doi.org/10.1152/jappl.1979.46.1.176
Abstract
Expiratory flow-volume curves and total pulmonary resistance were measured in 15 normal, anesthetized, upright bonnet (Macaca radiata) and 8 rhesus (M. mulatta) monkeys for use in studying the effects of specific air pollutants. Absolute maximum flows are about half that found in humans, but, if expressed, in vital capacities per second, monkey flows are about 4 times that of humans. Irrespective of flow rate, the typical shape of maximum expiratory flow-volume (MEFV) curves of rhesus monkeys is similar to that of normal young adults and that of bonnet monkeys is similar to that of normal older adults. Flow-limiting mechanisms that may determine MEFV curve shape and explain the differences and similarities of monkey and human MEFV curves are discussed. Differences in function between bonnet and rhesus monkeys apparently related to the concept of dysanaptic lung growth that evolved to subserve behavioral differences between the 2 spp. of monkey.This publication has 1 reference indexed in Scilit:
- Physical characteristics of the chest and lungs and the work of breathing in different mammalian speciesThe Journal of Physiology, 1961