Mutation Affecting Resistance of Escherichia coli K12 to Nalidixic Acid
- 1 September 1985
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 131 (9) , 2285-2292
- https://doi.org/10.1099/00221287-131-9-2285
Abstract
A new mutation, nalD, determining resistance of Escherichia coli to nalidixic acid (NAL) is reported. The nalD mutant described is resistant to NAL at 37.degree. C but sensitive at 30.degree. C. It is defective in penetration of NAL and glycerol through the outer membrane at 37.degree. C. The nalD mutation is located half-way between 89 and 89.5 min on the E. coli genetic map.Keywords
This publication has 7 references indexed in Scilit:
- Regulation of outer membrane porin protein synthesis in Escherichia coli K-12: ompF regulates the expression of ompCJournal of Bacteriology, 1983
- DNA Gyrase and the Supercoiling of DNAScience, 1980
- TYPES OF SPONTANEOUS NALIDIXIC-ACID RESISTANT MUTANTS OF ESCHERICHIA-COLI1980
- An Escherichia coli K12 mutant carrying altered ribosomal protein (S10)Biochemical and Biophysical Research Communications, 1977
- Identification of the outer membrane protein of E.coli that produces transmembrane channels in reconstituted vesicle membranesBiochemical and Biophysical Research Communications, 1976
- Maltose Transport in Escherichia coli K12. A Comparison of Transport Kinetics in Wild-Type and lamba-Resistant Mutants with the Dissociation Constants of the Maltose-Binding Protein as Measured by Fluorescence QuenchingEuropean Journal of Biochemistry, 1976
- Mechanism of Action of Nalidixic Acid on Escherichia coli II. Inhibition of Deoxyribonucleic Acid SynthesisJournal of Bacteriology, 1965