PHARMACOKINETICS OF POSITRON-LABELED 1,3-BIS(2-CHLOROETHYL)NITROSOUREA IN HUMAN-BRAIN TUMORS USING POSITRON EMISSION TOMOGRAPHY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (7) , 3120-3124
Abstract
The nitrosoureas are widely used in the chemotherapy of brain tumors. In 6 brain tumor patients the kinetic behavior of positron-labeled 1,3-bis(2-chloroethyl)nitrosourea was measured in both the tumor and the normal brain with positron emission tomography. The distribution of radioactivity in plasma was also analyzed. The clearance of total radioactivity from the tumor was significantly slower than from the contralateral brain and plasma, indicating a different rate of 1,3-bis(2-chloroethyl)nitrosourea decomposition in the tumor than in normal brain.

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