INVITRO STUDIES ON H-2 LINKED UNRESPONSIVENESS .1. NORMAL HELPER CELLS TO (T,G)-A-L AND GAT IN LOW AND NON-RESPONDER MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 32  (3) , 291-299
Abstract
Lymphoid cells from unprimed high responder (C57BL/10) and low responder mice (B10.Br, B10.A, CBA) to (T,G)-A-L [synthetic polypeptide containing tyrosine, glutamic acid, alanine and lysine] and high responder (B10, B10.A) and non-responder (B10.G, DBA/I) mice to GAT [synthetic polypeptide containing glutamic acid, alanine and tyrosine] can be induced to form antigen specific T[thymus-derived]-helper cells in vitro under identical culture conditions. The helper cells induced from high and low or non-responder mice appear to be identical in efficiency, antigen concentration requirement for induction and induction kinetics.