The Herpes Simplex Virus Type 1 Locus That Encodes the Latency-Associated Transcript Enhances the Frequency of Encephalitis in Male BALB/c Mice
Open Access
- 15 November 2005
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (22) , 14465-14469
- https://doi.org/10.1128/jvi.79.22.14465-14469.2005
Abstract
Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes that regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-matched female BALB/c mice. Deletion of LAT coding sequences reduced the frequency of encephalitis. A recombinant virus containing the first 1.5 kb of the LAT coding sequence induces levels of encephalitis in male BALB/c mice similar to those induced by wild-type HSV-1.Keywords
This publication has 42 references indexed in Scilit:
- Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter regionVirus Research, 2005
- A Locus on Mouse Chromosome 6 That Determines Resistance to Herpes Simplex Virus Also Influences Reactivation, While an Unlinked Locus Augments Resistance of Female MiceJournal of Virology, 2003
- The Gene That Encodes the Herpes Simplex Virus Type 1 Latency-Associated Transcript Influences the Accumulation of Transcripts (Bcl-x L and Bcl-x S ) That Encode Apoptotic Regulatory ProteinsJournal of Virology, 2003
- A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected RabbitsJournal of Virology, 2002
- The 2-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Has a Half-Life of Approximately 24 Hours in SY5Y and COS-1 CellsJournal of Virology, 2002
- Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with RabbitsJournal of Virology, 2001
- ex differences in immune responses to cephalothin in guinea pigs.The Journal of Toxicological Sciences, 1998
- Herpes Simplex Virus Infections of the Central Nervous SystemDrugs, 1991
- Mapping of Low Abundance Latency-associated RNA in the Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus Type 1Journal of General Virology, 1990
- Latent Herpes Simplex Virus in Human Trigeminal GangliaNew England Journal of Medicine, 1987