The Effects of Intra-articular198Au Instillations on Articular Cartilage
- 1 June 1972
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 103 (3) , 685-690
- https://doi.org/10.1148/103.3.685
Abstract
An experiment was devised to determine the effects of radiogold instillation on intra-articular tissue. Adult and weanling rats were injected with doses of 198Au ranging from 1 to 10 mCi. Radiation-induced damage to articular cartilage occurred only in wean1ing rats at extremely high doses (2.5-5 mCi). Adult rat articular cartilage is extremely resistant to radiation damage and to high doses of 198Au(5-10 mCi). Experimental evidence indicates a safety factor of 100 to 1000 X exists in the dose (1mCi/0.1 ml) used clinically for the treatment of rheumatoid arthritis.Keywords
This publication has 0 references indexed in Scilit: