Structure of Colloidal Bismuth Subcitrate (CBS) in Dilute HCl: Unique Assembly of Bismuth Citrate Dinuclear Units ([Bi(cit)2Bi]2-)
- 20 September 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (41) , 12408-12409
- https://doi.org/10.1021/ja037019x
Abstract
Colloidal bismuth subcitrate (CBS, De-Nol) has been used for several decades for the treatment of gastric and duodenal ulcers, and Helicobacter pylori infection together with antibiotics. The solubility of CBS in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3. CBS was crystallized in dilute HCl at pH 3, and unique assembly of three basic bismuth citrate dimeric units ([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D polymer.Keywords
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