Embryotoxic Effects of Acrolein, Methacrylates, Guanidines and Resorcinol on Three Day Chicken Embryos

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Abstract
Acrolein, four methacrylates, two guanidine compounds and resorcinol were tested for embryotoxicity on three day chicken embryos. The most potent chemical was acrolein, with the ED50 0.05 μmol per egg for the total effect, including deaths and malformations. The substances next in potency were N,N'‐di‐o‐tolyl‐guanidine and N,N‐diphenylguanidine, with ED50 values 0.17 and 0.20 μmol per egg, respectively. Resorcinol and the methacrylates had ED50 values ranging from 2.4 to 22.0 μmol per egg. Acrolein, diphenylguanidine, tetrahydrofururylmethacrylate and trimethylolpropanetrimethacrylate caused the largest amounts of malformed embryos.