Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation
Open Access
- 1 February 2005
- journal article
- review article
- Published by Springer Nature in Cell Research
- Vol. 15 (2) , 92-96
- https://doi.org/10.1038/sj.cr.7290271
Abstract
Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFs often exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemical mechanisms of action of the two KLFs in the context of growth regulation.Keywords
This publication has 42 references indexed in Scilit:
- All‐trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Krüppel‐like factor 5FEBS Letters, 2004
- Krüppel-like factor 5 mediates the transforming activity of oncogenic H-RasOncogene, 2004
- A Transforming Growth Factor-β Control Element Required for SM α-Actin Expression in Vivo Also Partially Mediates GKLF-dependent Transcriptional RepressionJournal of Biological Chemistry, 2003
- Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecityOncogene, 2003
- KLF5 is frequently deleted and down‐regulated but rarely mutated in prostate cancerThe Prostate, 2003
- Transcriptional Profiling of Krüppel-like Factor 4 Reveals a Function in Cell Cycle Regulation and Epithelial DifferentiationJournal of Molecular Biology, 2003
- A possible tumor suppressor role of the KLF5 transcription factor in human breast cancerOncogene, 2002
- Initial sequencing and analysis of the human genomeNature, 2001
- The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 PromoterJournal of Biological Chemistry, 2000
- Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factorNucleic Acids Research, 1998