Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity fromOmphalotus OleariusII. Isolation and Structure Determination
- 1 April 1997
- journal article
- research article
- Published by Taylor & Francis in Natural Product Letters
- Vol. 10 (1) , 33-38
- https://doi.org/10.1080/10575639708043692
Abstract
The structure of the potent nematicide omphalotin, isolated from the mycelia of the basidiomycete Omphalotus olearius, was determined by spectroscopic techniques. Omphalotin is a cyclic dodecapeptide consisting of 3 glycine, 5 valine, 3 isoleucine and 1 tryptophane, and 9 of the 12 β-nitrogens are methylated. HMBC and NOESY correlations between the N-methyl groups and the β-carbons/β-hydrogens established the sequence of amino acids.Keywords
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