ACCELERATION OF MYELOID RECOVERY FROM CYCLOPHOSPHAMIDE-INDUCED LEUKOPENIA BY PRETREATMENT WITH BACILLUS CALMETTE-GUERIN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (4) , 1049-1051
Abstract
Treatment of C57BL/6 mice [lymphoma] with BCG i.p. 8 days prior to the induction of leukopenia by cyclophosphamide (300 mg/kg i.p.) significantly (P < 0.002) increased peripheral granulocyte counts on each day during the recovery from leukopenia. The recovery of lymphocyte counts was unaffected by BCG treatment. The accelerated granulocyte recovery apparently was the result of an earlier initiation of the recovery process rather than of the release of stored granulocytes. BCG may have clinical value as a stimulator of myelopoiesis in patients rendered leukopenic by antineoplastic chemotherapy.