Mouse spinal cord in cell culture. IV. Modulation of inhibitory synaptic function
- 1 September 1977
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 40 (5) , 1178-1187
- https://doi.org/10.1152/jn.1977.40.5.1178
Abstract
When dissociated cell cultures of the fetal mouse spinal cord were grown chronically in the presence of glycine-containing medium, inhibitory synaptic activity were suppressed and paroxysmal neuronal activity was increased. Glycine chemosensitivity, assessed by iontophoretic application of glycine, was also suppressed. When cultures grown in the presence of glycine were acutely switched to glycine free medium, glycine sensitivity was quickly restored only after several (> 6) hours. Upon EM examination no abnormality of a specific synaptic type were evident in cultures grown in glycine.This publication has 7 references indexed in Scilit:
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- Mouse spinal cord in cell culture. II. Synaptic activity and circuit behaviorJournal of Neurophysiology, 1977
- Mouse spinal cord in cell culture. III. Neuronal chemosensitivity and its relationship to synaptic activityJournal of Neurophysiology, 1977
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