A monoclonal antibody reacting with human basophils
Open Access
- 1 May 1987
- journal article
- Published by American Society of Hematology in Blood
- Vol. 69 (5) , 1414-1418
- https://doi.org/10.1182/blood.v69.5.1414.1414
Abstract
Bsp-1 is an IgM murine monoclonal antibody raised against the human erythroblastic leukemia cell line (HEL) that reacts with basophils but not neutrophils or eosinophils. Western blotting techniques showed that Bsp-1 reacts with a 45-kilodalton surface antigen on HEL cells. The distribution of Bsp-1 antigen on leukemic cells is confined to a basophilic leukemia cell line, KU812, chronic myeloid leukemia with basophilia, and some cases of acute undifferentiated leukemia. Bsp-1 might therefore be a useful reagent for the study of basophil function and differentiation.Keywords
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