Barbiturate Physical Dependence in Mice: Effects of Neuroleptics and Diazepam on the Withdrawal Syndrome
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Clinical Toxicology
- Vol. 12 (4) , 427-434
- https://doi.org/10.3109/15563657809150013
Abstract
Diazepam (8 mg/kg) quickly and effectively reduced the incidence of withdrawal symptoms in phenobarbital dependent C57BL/6J male mice. In contrast, the neuroleptic agents employed (chlorpromazine, haloperidol, or reserpine) or α-methyl-p-tyrosine tended to exacerbate the withdrawal syndrome. Chlorpromazine and haloperidol were approximately equally potent in their effects; this would suggest that their antidopaminergic effects were not the primary mechanism of action for the increased incidence of withdrawal symptoms.This publication has 16 references indexed in Scilit:
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