31P relaxation rates to evaluate physiological events in the heart

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Abstract
The present study was performed to determine whether 31P NMR relaxation times (T1) of adenosine triphosphate (ATP) might be used to monitor the resultant altered myocardial physiology produced by ischemia and possibly to explain mechanisms of altered physiology. To this end, pre‐and post‐ischemic T1s were determined in hearts perfused in the Lan‐gendorff mode, using 31P NMR inversion recovery methods. In hearts without any pretreatment (CON), post‐ischemic ATP Ti values were significantly decreased compared with pre‐isch‐emic values (P T1 values were simlilar and were not significantly changed from pre‐ischemic values. These combined data suggest that T1s of ATP might be used to monitor altered myocardial physiology and could provide insight into mechanisms of alteration.