SIMULTANEOUS USE OF RAPIDLY ABSORBED AND SUSTAINED-RELEASE THEOPHYLLINE PREPARATIONS IN CHILDREN

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 43  (4) , 217-219
Abstract
Each of 12 asthmatic children received a single dose of Theolair (5 mg/kg) a single dose of Theolair SR (10 mg/kg) or both Theolair (3 mg/kg) and Theolair SR (10 mg/kg) on 3 separate days. Administration of both preparations together was followed by serum theophylline concentrations significantly higher than Theolair alone at 2-12 h and significantly higher than Theolair SR alone at every time except 6 h. This theophylline administration method may be useful in the asthmatic patient who requires medication only intermittently.