Tec homology (TH) adjacent to the PH domain
- 22 August 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 350 (2-3) , 263-265
- https://doi.org/10.1016/0014-5793(94)00783-7
Abstract
The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Ras GTPase activating protein and a human interferon-γ binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein—protein interactions.Keywords
This publication has 26 references indexed in Scilit:
- Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid miceHuman Molecular Genetics, 1994
- Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain FunctionBiochemical and Biophysical Research Communications, 1993
- The PH domain: a common piece in the structural pathcwork of signalling proteinsTrends in Biochemical Sciences, 1993
- Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID MiceScience, 1993
- Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency GenesScience, 1993
- Pleckstrin domain homologyNature, 1993
- A putative modular domain present in diverse signaling proteinsCell, 1993
- Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemiaCell, 1993
- The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinasesNature, 1993
- Eukaryotic protein kinasesCurrent Opinion in Structural Biology, 1991