Tissue atenolol levels following chronic β-adrenoceptor blockade using oral atenolol in dogs

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Abstract
Tissue atenolol concentrations are high following chronic continuous β-adrenoceptor blockade in dogs. Furthermore, significant concentrations of this poorly lipid soluble drug are found within the central nervous system after chronic dosing. It is suggested that all β-adrenoceptor blocking agents may enter the central nervous system in significant and sufficient quantities to account for a central antihypertensive action of this group of compounds. Sequestration of β-adrenoceptor agents in the CNS or other tissues may account for other clinically observed effects including adaptive effects.