Use of mitomycin C for treatment of keloid: A preliminary report
- 30 April 2005
- journal article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 132 (4) , 598-601
- https://doi.org/10.1016/j.otohns.2004.09.060
Abstract
Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision. Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed. All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm. MC application following scar resection appears to be effective in treatment of keloid. As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.Keywords
This publication has 20 references indexed in Scilit:
- Effect of Topical Mitomycin on Skin Wound ContractionArchives of Facial Plastic Surgery, 2003
- Effect of Mitomycin C on Keloid Fibroblasts: An In Vitro StudyAnnals of Plastic Surgery, 2003
- International Clinical Recommendations on Scar ManagementPlastic and Reconstructive Surgery, 2002
- Idiopathic Subglottic Stenosis RevisitedAnnals of Otology, Rhinology & Laryngology, 2002
- Mitomycin C for the Prevention of Adhesion Formation after Endoscopic Sinus Surgery: A Randomized, Controlled StudyOtolaryngology -- Head and Neck Surgery, 2002
- The Role of Mitomycin in the Prevention and Treatment of Scar Formation in the Pediatric Aerodigestive TractJAMA Otolaryngology–Head & Neck Surgery, 2002
- Treating the Elusive KeloidJAMA Otolaryngology–Head & Neck Surgery, 2001
- An Investigation of Airway Wound Healing Using a Novel in vivo ModelThe Laryngoscope, 2001
- Safety and Efficacy of Topical Mitomycin C in Myringotomy PatencyOtolaryngology -- Head and Neck Surgery, 2001
- Results of intraoperative mitomycin C application in dacryocystorhinostomyBritish Journal of Ophthalmology, 2000