Proliferating bipotential glial progenitor cells in adult rat optic nerve
- 1 February 1986
- journal article
- Published by Springer Nature in Nature
- Vol. 319 (6053) , 499-502
- https://doi.org/10.1038/319499a0
Abstract
We have shown previously that the rat optic nerve contains three types of macroglial cells--oligodendrocytes and two types of astrocytes--which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16), while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7-10 (P7-10), respectively. Here we report that proliferating bipotential oligodendrocyte-type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.Keywords
This publication has 24 references indexed in Scilit:
- A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineagesDevelopmental Biology, 1985
- Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiationCell, 1985
- Differentiation of a bipotential glial progenitor cell in single cell microcultureNature, 1985
- Effects of neonatal transection on glial cell development in the rat optic nerve: evidence that the oligodendrocyte-type 2 astrocyte cell lineage depends on axons for its survivalJournal of Neurocytology, 1984
- Two glial cell lineages diverge prenatally in rat optic nerveDevelopmental Biology, 1984
- A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture mediumNature, 1983
- Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.Proceedings of the National Academy of Sciences, 1982
- Monoclonal antibody to a plasma membrane antigen of neurons.Proceedings of the National Academy of Sciences, 1979
- Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in cultureBrain Research, 1979
- Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescenceBrain Research, 1972