BIOCHEMICAL-STUDIES ON MOLYBDENUM TOXICITY IN RATS - EFFECTS OF HIGH PROTEIN FEEDING

  • 1 January 1981
    • journal article
    • research article
    • Vol. 51  (4) , 401-409
Abstract
Chronic oral administration of ammonium molybdate in rats markedly retarded the growth rate of rats, and high protein diet partially reversed this condition. The activities of several enzymes i.e., acid phosphatase, alkaline phosphatase, glucose-6-phosphatase, succinic dehydrogenase, glutamate oxaloacetate transaminase, inorganic pyrophosphatase and acetylcholinesterase, in different tissues and serum levels of luteinizing hormone, FSH, prolactin and cortisol were altered due to the toxicity, and high protein diet fed group of animals showed almost normal values for some of these parameters. Normal histological pattern of liver and kidney tissues were altered by Mo toxicity. Significant increases of basophilic substances were observed in the cytoplasm of the liver cells of the toxic animals which was counteracted by a feeding high protein diet.