Identification of 1,4‐thiomorpholine‐3‐carboxylic acid (TMA) in normal human urine
- 19 June 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 250 (1) , 75-77
- https://doi.org/10.1016/0014-5793(89)80688-x
Abstract
The sulfur‐containing cyclic imino acid 1,4‐thiomorpholine‐3‐carboxylic acid (TMA) has been identified in normal human urine. After the enrichment procedure with ion‐exchange chromatography, the urine extracts were reacted with diazomethane. Gas‐liquid chromatography revealed the presence of two peaks with the same retention times exhibited by authentic TMA after the same derivatization. The two compounds have been identified by mass‐spectrometry as the monomethylated and dimethylated derivatives of TMA. This result represents the first indication of the occurrence of TMA in a mammalian sample.Keywords
This publication has 13 references indexed in Scilit:
- Purification and characterization of a ketimine‐reducing enzymeEuropean Journal of Biochemistry, 1988
- Transamination of l-cystathionine and related compounds by bovine brain glutamine transaminaseNeurochemistry International, 1987
- Hexahydro-1,4-thiazepine-3,5-dicarboxylic acid and thiomorpholine-3,5-dicarboxylic acid are present in normal human urine.Proceedings of the National Academy of Sciences, 1987
- Transamination of L-cystathionine and related compounds by a bovine liver enzyme. Possible identification with glutamine transaminaseBiochimica et Biophysica Acta (BBA) - General Subjects, 1986
- The transamination of l-cystathionine, l-cystine and related compounds by a bovine kidney transaminaseEuropean Journal of Biochemistry, 1986
- 1,4‐Thiomorpholine‐3,5‐dicarboxylic acid, a novel cyclic imino acid detected in bovine brainFEBS Letters, 1985
- Gas chromatographic determination of thiazine and thiazepine derivatives of biological interestJournal of Chromatography A, 1984
- Interaction between 1,4-thiazine derivatives and d-amino-acid oxidaseBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
- β-Elimination of β-halo substrates by D-amino acid transaminase associated with inactivation of the enzyme. Trapping of a key intermediate in the reactionBiochemistry, 1978
- The Synthesis of L-1,4-Thiazane-3-carboxylic Acid 1-Oxide1The Journal of Organic Chemistry, 1964