Oligonucleotide Conjugates: Alteration of the Pharmacokinetic Properties of Antisense Agents

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 969-973
https://doi.org/10.1080/15257779508012513

Abstract

Cholic acid, cholesterol, several polyamines and polyethylene glycols were conjugated to antisense oligonucleotides targeted to human or murine intercellular adhesion molecule-1 (ICAM-1) mRNA to study their effects on cellular absorption.

Keywords

PHARMACOKINETIC
CONJUGATES
ADHESION
ABSORPTION
GLYCOLS
POLYETHYLENE
CHOLIC
INTERCELLULAR
MURINE
POLYAMINES

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