Calcium and Strontium Uptake by Rat Liver and Kidney Mitochondria.

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Abstract
Rat liver and kidney mitochondria were incubated at 30 [degree]C in solutions varying in Ca, Sr, ATP and cytochrome C concentration. The addition of 0.9 [mu]M Ca decreased both Ca45 and Sr85 uptake with Sr85 being reduced to a greater degree. The reverse was true when 0.9 [mu]M of Sr was added to the medium; both Sr85 and Ca45 were increased with the increase in Sr85 being greater. Addition of equal amounts of Sr and Ca to the medium increased Sr85 and Ca45 uptake to the extent observed with strontium above. ATP was required for the uptake of Sr85 and Ca45 by kidney mitochondria, while cytochrome C was not. Results with liver mitochondria were more variable and the requirement of ATP appeared to be influenced by the Ca in the medium.