Eye Drops and Diarrhea

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Abstract
ECHOTHIOPHATE iodide (Phospholine iodide) is administered as eye drops principally for the control of intraocular pressure in glaucoma. When introduced into the conjunctival sac, it produces an intense and prolonged miosis. It is a long acting parasympathomimetic (cholinergic) agent owing to its potent inhibition of cholinesterase.1 In addition to the local effect in the eye, there is systemic absorption, which is sufficient to produce a measurable decrease in the acetylcholinesterase activity of the red blood cells.2 3 4 Although symptoms resulting from systemic absorption are unusual the effects of cholinergic stimulation such as diarrhea, intestinal cramps, vomiting and paresthesia have been reported. . . .