EFFECT OF DIHYDROXY-2-AMINOTETRALINS (DATS) ON DOPAMINE AND BETA TYPE ADENYLATE CYCLASES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (2) , 213-224
Abstract
A number of DAT were studied for agonist activity with rat brain dopamine adenylate cyclase and rat erythrocyte .beta. type adenylate cyclases and the most potent ones were found among the 6,7-DAT [dihydroxy-2-aminotetralins] and the 5,6-DAT, respectively. None of the compounds tested possessed antagonist activity. The observed activities were not expected on the basis of structural analysis of model compounds such as apomorphine and 6,7-dihydroxy-1-benzyltetrahydroisoquinoline. A new view was constructed which suggests that the nitrogens of the DAT compounds were positioned better than those of the model compounds with regard to their binding sites.