Effects of Cortisone on Trichinella spiralis Infections in Non-Immunized Mice

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Abstract
Two different schedules of cortisone treatment of non-immunized mice receiving an infection with T. spiralis resulted in longer persistence of more adult worms in the intestine, and establishment of more larval worms in the musculature, than in controls. Results lend strong support to the view that non-immunized, mature mice develop a delayed measurable acquired immunity against an initial infection with T. spiralis. They show that treatment of such mice with cortisone, beginning shortly prior to infection and extending through the period when this acquired immunity normally would manifest itself, prevented or greatly weakened the expression of the immunity.