Relationship of changing bronchial caliber to respiration in the dog

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Abstract
A cylindrical bronchial catheter is described for recording moment-to-moment changes in caliber during spontaneous respiration in lightly anesthetized dogs. Caliber changes due to bronchial transmural pressure and altered bronchial tone are measured separately and collectively. Transmural pressure changes, because of the elastic character of bronchi, are shown to alter caliber significantly. Histamine-induced alterations in bronchial tone are capable of dominating transmural pressure influences on caliber. Following small doses of intravenous histamine, dynamic compliance decreases progressively and the decrease is related in time and degree to changes in bronchial caliber. Recovery is prompt and sustained. Decrease in compliance occurs without significant increase in airway resistance or change in functional residual capacity. These observations suggest that a dominant factor influencing dynamic compliance is alteration of bronchomotor tone. bronchial distensibility; bronchoconstriction; bronchomotor tone; transbronchial pressure; compliance; mean airway resistance; histamine Mecholyl Submitted on January 6, 1964

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