Cardiovascular β-adrenoceptor sensitivity of undernourished subjects
Open Access
- 1 July 1987
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 58 (1) , 5-11
- https://doi.org/10.1079/bjn19870063
Abstract
1. Eleven normal-weight male subjects (weight/height2 (W/H2) 19.0-225) from a good socio-economic background and on ad lib. food intake, and eight undernourished male labourers (W/H2 16.4–18.6) on low energy intakes, were studied.2. Comparison of cardiovascular responses to increasing single doses of the β-agonist, isoproterenol, showed a significantly greater positive chronotropic dose response in the undernourished subjects.3. Cardiovascular responses to head-up tilt were similar in both the normal-weight and undernourished subjects.4. Undernourished individuals may show an increase in β-adrenoceptor sensitivity which may be akin to a denervation type of supersensitivity as a result of a nutrition-related reduction in sympathetic activity.This publication has 26 references indexed in Scilit:
- Contribution of the vagus to the haemodynamic responses following intravenous boluses of isoprenaline.British Journal of Clinical Pharmacology, 1983
- Triiodothyronine-induced Thyrotoxicosis Increases Mononuclear Leukocyte β-Adrenergic Receptor Density in ManJournal of Clinical Investigation, 1981
- Regulation of Human Leukocyte Beta Receptors by Endogenous CatecholaminesJournal of Clinical Investigation, 1981
- Elevation of beta-adrenergic receptor density in human lymphocytes after propranolol administration.Journal of Clinical Investigation, 1980
- EFFECT OF CATECHOLAMINE REPLACEMENT WITH LEVODOPA ON THE METABOLIC RESPONSE TO SEMISTARVATIONThe Lancet, 1979
- Reciprocal Changes in Serum Concentrations of 3,3′,5′-Triiodothyronine (Reverse T3) and 3,3′5-Triiodothyronine (T3) in Systemic IllnessesJournal of Clinical Endocrinology & Metabolism, 1975
- Circulating Thyroid Hormones and Thyrotropin in Adult Patients with Protein-Calorie MalnutritionJournal of Clinical Endocrinology & Metabolism, 1975
- Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 YearsBritish Journal of Nutrition, 1974
- Intravenously administered isoproterenol sulfate dose-response curves in manArchives of internal medicine (1960), 1972
- A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranololArchives of internal medicine (1960), 1972