Cerebral White-Matter Hypoplasia
- 1 March 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 34 (3) , 137-141
- https://doi.org/10.1001/archneur.1977.00500150023003
Abstract
• Twelve patients, including three sisters, with lifelong severe intellectual impairment and neurologic defects were found to have generalized hypoplasia of the cerebral white matter, with corresponding enlargement of the ventricular system. Gray-matter structures were remarkably intact. Reactive cellular changes (gliosis, phagocytosis, inflammation) were absent. To our knowledge, this particular syndrome has not previously been delineated in the extensive literature on cerebral palsy. The abnormalities in these cases could result from the effects of a selectively acting tissuedamaging factor, such as has been postulated in perinatal telencephalic leukoencephalopathy, but the factors underlying the disorder are still unknown.This publication has 3 references indexed in Scilit:
- An epidemiologic study of perinatal telencephalic leucoencephalopathy in an autopsy populationJournal of the Neurological Sciences, 1973
- Pathogenesis and Evolution of Periventricular Leukomalacia in InfancyArchives of Neurology, 1972
- Über eine besondere Reaktionsweise des unreifen ZentralnervengewebesZeitschrift für die gesamte Neurologie und Psychiatrie, 1920