THE ASSOCIATION OF PRETRANSPLANT NATIVE NEPHRECTOMY WITH DECREASED RENAL ALLOGRAFT REJECTION

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Abstract
Analysis of 2808 first and 823 second or subsequent cadaveric renal allograft recipients transplanted between June 1977-July 1982 as part of the Southeastern Organ Procurement Foundation (SEOPF) Prospective Study was performed to determine the influence of pretransplant bilateral native nephrectomy (BNN) on graft and patient outcome. A highly significant increase in overall growth survival was associated with BNN in 1st transplant recipients (P < 0.003) but not in regrafted patients. No increased graft survival was seen in patients receiving BNN at the time of the transplant operation. The improvement in graft survival associated with BNN appeared to be the result of a significant decrease in the incidence of graft loss caused by rejection and especially accelerated acute rejection (P < 0.007). Comparing actuarial graft survival for 1st graft recipients that had BNN prior to transplantation (n = 434) with those who had no nephrectomy (n = 2240) showed differences of 62% .+-. 3 vs. 52% .+-. 1 and 46% .+-. 3 vs. 38% .+-. 2 at 1 and 3 yr, respectively. Analysis of 1st graft survival stratified for other factors known to influence outcome showed that the beneficial influence of BNN was independent of transfusion status or the number of transfusions given, use of antilymphocyte serum, pretransplant splenectomy, HLA match or time on dialysis. The most-striking increase in graft survival associated with BNN was seen in patients with evidence of presensitization as manifested by a positive panel reactive antibody (PRA) and in patients having delayed function (ATN) posttransplantation. The beneficial association of BNN was also independent of the primary cause of renal failure or the specific indication leading to nephrectomy. These results suggest that patients receiving native bilateral nephrectomy prior to transplantation have a reduced incidence of graft loss from rejection by some as yet unexplained mechanism.

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