TREATMENT OF ANXIETY/DEPRESSIVE CONDITIONS IN THE ELDERLY: A DOUBLE-BLIND COMPARATIVE STUDY OF MOTIVAL AND AMITRIPTYLINE
- 1 November 1975
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Age and Ageing
- Vol. 4 (4) , 226-231
- https://doi.org/10.1093/ageing/4.4.226
Abstract
A double-blind two-group comparison of fluphenazine/nortriptyline (F/N) with amitriptyline in 72 patients aged 65 or over suffering from mixed states of anxiety and depression, each treated for four weeks, showed F/N to be significantly superior to amitriptyline by Day 7 in terms of patients' self-ratings and clinicians' ratings. Patients' preference for F/N was even more pronounced by Day 28 (PP P <0.05) in the amitriptyline group than the F/N group. The implications of these results for the treatment of emotional disturbances in the elderly are discussed.Keywords
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