Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
Top Cited Papers
Open Access
- 9 February 2005
- journal article
- review article
- Published by Oxford University Press (OUP) in Toxicological Sciences
- Vol. 86 (1) , 6-19
- https://doi.org/10.1093/toxsci/kfi110
Abstract
Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity are highlighted.Keywords
This publication has 169 references indexed in Scilit:
- Multiple regulatory elements with spatially and temporally distinct activities control neurogenin1 expression in primary neurons of the zebrafish embryoMechanisms of Development, 2003
- Aryl hydrocarbon receptors: diversity and evolution11Invited review for Chemico-Biological Interactions.Chemico-Biological Interactions, 2002
- Effective targeted gene ‘knockdown’ in zebrafishNature Genetics, 2000
- Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT)Biochemical and Biophysical Research Communications, 1996
- Stages of embryonic development of the zebrafishDevelopmental Dynamics, 1995
- Exogenous retinoic acid causes specific alterations in the development of the midbrain and hindbrain of the zebrafish embryo including positional respecification of the Mauthner neuronMechanisms of Development, 1995
- Toxicity of mercury, copper, nickel, lead, and cobalt to embryos and larvae of zebrafish,Brachydanio rerioArchives of Environmental Contamination and Toxicology, 1991
- Cell lineage and developmental potential of cells in the zebrafish embryoTrends in Genetics, 1988
- Production of transgenic fish: introduction and expression of chicken δ-crystallin gene in medaka embryosCell Differentiation, 1986
- Morphological changes in monkeys consuming a diet containing low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxinFood and Cosmetics Toxicology, 1977