Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit
- 1 January 1990
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 07 (7) , 691-696
- https://doi.org/10.1023/a:1015803202857
Abstract
The relationship between the tissue-to-plasma partition coefficients ( Kp) and drug lipophilicity was investigated using highly lipophilic drugs with apparent partition coefficients of 150 or above...This publication has 20 references indexed in Scilit:
- Effects of cimetidine on quinidine distribution and tissue pH in rats.Journal of Pharmacobio-Dynamics, 1989
- Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure—Pharmacokinetic relationshipsJournal of Pharmacokinetics and Biopharmaceutics, 1988
- A physiologically based pharmacokinetic model for biperiden in animals and its extrapolation to humans.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Effects of Fasting on Biperiden Pharmacokinetics in the RatJournal of Pharmaceutical Sciences, 1987
- Fundamental pharmacokinetic properties of biperiden: tissue distribution and elimination in rabbits.Journal of Pharmacobio-Dynamics, 1986
- Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in ratsJournal of Pharmacokinetics and Biopharmaceutics, 1985
- Prediction of the volumes of distribution of basic drugs in humans based on data from animalsJournal of Pharmacokinetics and Biopharmaceutics, 1984
- Pharmacokinetic Study on the Mechanism of Tissue Distribution of Doxorubicin: Interorgan and Interspecies Variation of Tissue-To-Plasma Partition Coefficients in Rats, Rabbits, and Guinea PigsJournal of Pharmaceutical Sciences, 1984
- Disease-induced Changes in the Plasma Binding of Basic DrugsClinical Pharmacokinetics, 1980
- Relationship between partition coefficients and apparent volumes of distribution for basic drugs. II.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978