Chromosome Studies in Human Leukemia. IV. Myeloproliferative Syndrome and Other Atypical Myeloid Disorders

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Abstract
Chromosome studies are reported in 7 cases of the myeloproliferative syndrome (polycythemia vera, myelofibrosis, myeloid metaplasia), 3 cases of chronic granulocytic leukemia (monocytoid form), and 3 cases of atypical myeloid proliferation in children. Chromosome abnormalities were observed in only 4 patients, all with the myeloproliferative syndrome. Two patients had converted to granulocytic leukemia; the other 2 had been treated with P32 for polycythemia vera. Although no consistent chromosome change was observed, the 5 abnormal stemlines found in the 4 patients involved chromosomes from only 3 groups: 7 to 12, 13 to 15, and 16 to 18. The findings indicate that the disease entities investigated should not be considered variants of chronic granulocytic leukemia, which is characterized by a consistent abnormality of chromosome #21.

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