p -Chlorophenylalanine-Induced Chemical Manifestations of Phenylketonuria in Rats
- 14 April 1967
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3772) , 248-250
- https://doi.org/10.1126/science.156.3772.248
Abstract
p -Chlorophenylalanine, a potent inhibitor of phenylalanine hydroxylase in vivo, has been used to simulate phenylketonuria in rats. This inhibitor, when administered with phenylalanine, produces marked elevation of blood and tissue phenylalanine without an increase in tyrosine. Disproportionate ratios of phenylalanine to tyrosine are characteristic of phenylketonuria in humans. The use of p -chlorophenylalanine permits the production of this characteristic amino acid imbalance in experimental animals.Keywords
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