A Self-Regulated Insulin Delivery System Using Boronic Acid Gel

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Abstract
A novel polymer system sensitive to glucose concentration has been studied as a can didate material for chemically regulated insulin release system. Phenylboronic acid is able to form reversible binding to cis-diol substances. A glucose responsive insulin release system has been studied with utilization of phenylboronic acid polymers for the key material in the exchange reaction between gluconic acid modified insulin (G-Ins) and glucose. The released concentration of G-Ins from the polymer was pulsatile in response to the repeated stepwise concentration changes of glu cose. The linearity between glucose concentration and peak height of released G-Ins and the release response demonstrated no lag time to changes in glucose concentration were other important finites. The phenylboronic acid polymer shows considerable promise for use in a self-regulating insulin delivery system.