Expression of a Functional Secreted YopN-TyeA Hybrid Protein inYersinia pestisIs the Result of a +1 Translational Frameshift Event
- 1 August 2004
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 186 (15) , 5160-6
- https://doi.org/10.1128/jb.186.15.5160-5166.2004
Abstract
YopN is a secreted protein that prior to secretion directly interacts with the cytosolic SycN/YscB chaperone complex and TyeA. This study identifies a secreted YopN-TyeA hybrid protein that is expressed by Yersinia pestis, but not by Yersinia enterocolitica. DNA sequence analysis and site-directed mutagenesis studies demonstrate that the hybrid protein is the result of a +1 translational frameshift event.Keywords
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