Biological Assay of Human Kidney Tumors by Means of Heterologous Ocular Transplantations: A Study of Clear-Cell Carcinoma, Granular-Cell Carcinoma and Papuliferous Epithelioma of the Kidney

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Abstract
The study was undertaken to determine the biologic activity of human kidney tumors by means of heterologous transplantation. Material from papilliferous epithelioma, clear-cell carcinoma and granular-cell carcinoma (2 mm. of tissue) was transplanted into the anterior chamber of the eye of guinea pigs. It was found that the relatively benign papilliferous epithelioma could be heterologously maintained, whereas the highly malignant granular-cell type gave negative results. The clear-cell type tumor apparently converted to the granular-cell variety.