Abstract reward and punishment representations in the human orbitofrontal cortex
Top Cited Papers
- 1 January 2001
- journal article
- clinical trial
- Published by Springer Nature in Nature Neuroscience
- Vol. 4 (1) , 95-102
- https://doi.org/10.1038/82959
Abstract
The orbitofrontal cortex (OFC) is implicated in emotion and emotion-related learning. Using event-related functional magnetic resonance imaging (fMRI), we measured brain activation in human subjects doing an emotion-related visual reversal-learning task in which choice of the correct stimulus led to a probabilistically determined 'monetary' reward and choice of the incorrect stimulus led to a monetary loss. Distinct areas of the OFC were activated by monetary rewards and punishments. Moreover, in these areas, we found a correlation between the magnitude of the brain activation and the magnitude of the rewards and punishments received. These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money.Keywords
This publication has 34 references indexed in Scilit:
- The Brain and EmotionJournal of Psychophysiology, 2001
- Characterizing the Hemodynamic Response: Effects of Presentation Rate, Sampling Procedure, and the Possibility of Ordering Brain Activity Based on Relative TimingNeuroImage, 2000
- Functional–Anatomic Study of Episodic Retrieval: II. Selective Averaging of Event-Related fMRI Trials to Test the Retrieval Success HypothesisNeuroImage, 1998
- Effects of orbital frontal and anterior cingulate lesions on object and spatial memory in rhesus monkeysNeuropsychologia, 1997
- Deciding Advantageously Before Knowing the Advantageous StrategyScience, 1997
- Dissociation in prefrontal cortex of affective and attentional shiftsNature, 1996
- Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage.Journal of Neurology, Neurosurgery & Psychiatry, 1994
- Insensitivity to future consequences following damage to human prefrontal cortexCognition, 1994
- Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkeyJournal of Comparative Neurology, 1992
- Limbic lesions and the problem of stimulus—Reinforcement associationsExperimental Neurology, 1972