The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to13C and15N NMR studies: quantitative fragmentation to cyanate
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 1726-1728
- https://doi.org/10.1039/c39910001726
Abstract
The use of 13C NMR spectroscopy to monitor the decomposition of [13CO]N-methyl-N-nitrosourea, and of 15N NMR spectroscopy to follow the decomposition of [15NH2]N-methyl-N-nitrosourea, both in aqueous phosphate buffer at pH 7, shows the initial product to be cyanate rather than carbamate; the cyanate reacts with phosphate to give carbamoyl phosphate.Keywords
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