Effects of Progressive Desialylation on the Rate of Disappearance of Immunoreactive HCG from Plasma in Rats
- 1 July 1971
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 89 (1) , 11-15
- https://doi.org/10.1210/endo-89-1-11
Abstract
A specific radioimmunoassay was used to measure concentrations of immunoreactive hormone in plasma samples taken at intervals following injection of intact and variably desialylated preparations of highly purified human chorionic gonadotropin (HCG) into pseudopregnant rats. Desialylation of HCG up to 25% decreased plasma half-life by 50% (from 25 to 11 min). Removal of sialic acid over the range of 25–62% resulted in a more profound reduction in plasma t½ (from 11 to less than 1 min) but desialylation greater than 62 % was without additional effect. The observations suggest that previously observed decrements in biologic activity following progressive desialylation of HCG result, in part, from changes in plasma half-life of the hormone. (Endocrinology 89: 11, 1971)Keywords
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