Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder

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Abstract
The parasympathetically denervated and distended rat urinary bladder was found to have increased 4-fold in weight when examined 3 wk postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The cells of the 2 layers apparently increase in size and number. Hyperplasia was suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.