Mesovarial Leiomyomas in Rats in a Chronic Toxicity Study of Soterenol Hydrochloride
Open Access
- 1 September 1971
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 8 (5-6) , 452-457
- https://doi.org/10.1177/0300985871008005-00607
Abstract
In an 18-month oral toxicity study of soterenol hydrochloride, a stimulant of the β-adrenergic receptors, mesovarial leiomyomas were observed in three of 30 low-dose, six of 30 middle-dose and 10 of 30 high-dose rats. There was also an increase in the prevalence of ovarian cysts and of focal hyperplasia of smooth muscle in the mesovaria in the treated rats, especially in the high-dose group.Keywords
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