EVIDENCE FOR A ROLE OF NITRIC OXIDE IN THE NEUROTRANSMITTER SYSTEM MEDIATING RELAXATION OF THE RAT ANOCOCCYGEUS MUSCLEC
- 1 December 1989
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 16 (12) , 933-938
- https://doi.org/10.1111/j.1440-1681.1989.tb02404.x
Abstract
SUMMARY: 1. The nitric oxide (NO) synthesis inhibitor NG‐monomethyl‐l‐arginine (l‐NMMA), but not d‐NMMA, inhibited the NANC‐mediated relaxations of the rat anococcygeus muscle, but did not affect the relaxation produced by sodium nitroprusside.2. The inhibitory effect of l‐NMMA was reversed by l‐arginine but not by d‐arginine, and prior exposure to l‐arginine blocked the effect of l‐NMMA.3. The noradrenergically mediated contractions of the anococcygeus elicited by field stimulation were slightly enhanced by l‐NMMA, but the response to noradrenaline was not affected.4. The results suggest that NANC transmission in the rat anococcygeus muscle involves the generation of NO from arginine.Keywords
This publication has 12 references indexed in Scilit:
- Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscleEuropean Journal of Pharmacology, 1989
- Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.Proceedings of the National Academy of Sciences, 1989
- A specific inhibitor of nitric oxide formation from l‐arginine attenuates endothelium‐dependent relaxationBritish Journal of Pharmacology, 1989
- Facilitation of noradrenaline release from sympathetic nerves in rat anococcygeus muscle by activation of prejunctional β-adrenoceptors and angiotensin receptorsBritish Journal of Pharmacology, 1988
- Regulation of the Release of Coexisting NeurotransmittersAnnual Review of Pharmacology and Toxicology, 1988
- Regulation Of The Release Of Coexisting NeurotransmittersAnnual Review of Pharmacology and Toxicology, 1988
- Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature, 1987
- Frequency- and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleenNeuroscience Letters, 1986
- Corelease of VIP and acetylcholine in relation to blood flow and salivary secretion in cat submandibular salivary glandActa Physiologica Scandinavica, 1982
- The rat anococcygeus muscle and its response to nerve stimulation and to some drugsBritish Journal of Pharmacology, 1972