INDUCED HELICAL CONFORMATION OF IONIC POLYPEPTIDES BY PHOSPHOLIPIDS SOLUBILIZED IN A NONIONIC SURFACTANT SOLUTION
- 1 March 1979
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (3) , 341-345
- https://doi.org/10.1111/j.1399-3011.1979.tb01890.x
Abstract
Phosphatidylcholine that has been solubilized in hexadecylpoly (oxyethylene) ether can induce a coil-to-helix transformation for poly(l-glutamic acid) in neutral solution. Similarly, solubilized phosphatidylserine promotes a helical conformation of poly(l-lysine) at neutral pH through complex formation. The mixed micelles of a phospholipid and a nonionic surfactant are thermodynamically stable and do not separate on standing. The nonionic surfactant here has no effect on the conformation of the two polypeptides.Keywords
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