The many faces of actin: matching assembly factors with cellular structures
Top Cited Papers
- 1 October 2007
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 9 (10) , 1110-1121
- https://doi.org/10.1038/ncb1007-1110
Abstract
Actin filaments are major components of at least 15 distinct structures in metazoan cells. These filaments assemble from a common pool of actin monomers, but do so at different times and places, and in response to different stimuli. All of these structures require actin-filament assembly factors. To date, many assembly factors have been identified, including Arp2/3 complex, multiple formin isoforms and spire. Now, a major task is to figure out which factors assemble which actin-based structures. Here, we focus on structures at the plasma membrane, including both sheet-like protrusive structures (such as lamellipodia and ruffles) and finger-like protrusions (such as filopodia and microvilli). Insights gained from studies of adherens junctions and the immunological synapse are also considered.Keywords
This publication has 132 references indexed in Scilit:
- Spatial and Temporal Relationships between Actin-Filament Nucleation, Capping, and DisassemblyCurrent Biology, 2007
- Retroviruses can establish filopodial bridges for efficient cell-to-cell transmissionNature Cell Biology, 2007
- Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological SynapseImmunity, 2007
- Two distinct modes of myosin assembly and dynamics during epithelial wound closureThe Journal of cell biology, 2007
- Actin turnover–dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severingThe Journal of cell biology, 2006
- The ARP2/3 complex: an actin nucleator comes of ageNature Reviews Molecular Cell Biology, 2006
- Role of fascin in filopodial protrusionThe Journal of cell biology, 2006
- Formin proteins: a domain-based approachTrends in Biochemical Sciences, 2005
- Molecular mechanisms of invadopodium formationThe Journal of cell biology, 2005
- Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in LamellipodiaThe Journal of cell biology, 1999