Trace Element Profiles in Individual Blood Cells from Patients with Down's Syndrome

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Abstract
The concentrations of trace elements in 3 different types of blood cells (erythrocytes, thrombocytes and neutrophils) were determined by nuclear microprobe analysis in 11 children with Down''s syndrome (DS) and compared with those in 13 controls. The median concentration of Cu in all 3 types of blood cells and that of Ca in erythrocytes were significantly higher in DS children than in controls. The median levels of Zn in erythrocytes, of Mn and Fe in erythrocytes and neutrophils, and of Mg in erythrocytes and thrombocytes were significantly lower in DS than in control children. In 10 of the 11 DS children, detectable erythrocyte levels of Ti were found, which is remarkable, since this was not observed in any of the cells from the control children.